This study aims to examine the physical changes in women's health in the context of grotesque aesthetics and to examine the interdisciplinary dialogue between art and health. The body, which is at the center of art, has been transformed by factors such as sociology, politics, faith and science from past to present. The representation of the body positioned with its perfection in art has been replaced by its opposite, the imperfect body. This new representation in art is important in terms of saving the body, which is considered imperfect, from being the other. While bodily differences caused by health problems challenge traditional norms of beauty, grotesque aesthetics reinterprets these differences from an artistic perspective. The effects of health problems on the body that cause deterioration in physical appearance change the way individuals perceive themselves and lead to social stigmatization. By making such bodies visible, art supports the psychosocial well-being of individuals and offers alternative narratives that question perceptions of beauty and normality. In this study, the concept of the grotesque body is analyzed through historical and modern artworks, and how art transforms body perception is discussed. It is emphasized that interdisciplinary art and health collaborations are an important tool for making sense of physical transformations in women's health and developing more inclusive health policies.